The Belgian Pediatric Clinical Research Network (BPCRN): Pediatric Trial Facilitation During and Beyond Conect4children

Abstract

Objective
The Belgian Pediatric Clinical Research Network (BPCRN) aims to promote pediatric clinical research by enhancing collaboration among stakeholders and facilitating high-quality trials. This manuscript outlines BPCRN’s growth, its role in the Innovative Medicines Initiative 2 conect4children (c4c) project, and its contributions to pediatric drug development in Belgium.

Methods
Summary of BPCRN’s activities since 2018, including its role in the c4c project. Data were collected from progress reports, internal databases, and interviews with investigators. The analysis highlights BPCRN’s operational activities, trial facilitation, governance structure, and collaborations with international partners.

Results
BPCRN now includes 15 pediatric study sites across Belgium, utilizing a single-point-of-contact model for efficient communication. The network supported six commercial and non-commercial trials under the c4c project and facilitated over 20 additional studies through collaborations with global partners like I-ACT for Children. A new governance framework was introduced, including an Advisory Board and Steering Committee to guide future growth and sustainability.

Conclusion
BPCRN evolved to become a key contributor to pediatric clinical research in Belgium, overcoming barriers like recruitment difficulties and methodological challenges. The network’s collaborative model and strategic governance will enable its continued expansion, ensuring that children have access to innovative and safe treatments. BPCRN’s success positions Belgium as a leading hub for pediatric clinical trials and addresses the unmet needs of pediatric patients.