Abstract
Background: Varicella is a well-known infectious disease caused by the varicella zoster virus. It usually is a self-limiting disease. However, severe complications requiring hospitalisation, and long-term sequelae can occur.
Methods: A critical analysis of the literature was performed to analyse arguments pro and contra universal vaccination.
Results: The currently licensed vaccines are highly effective in preventing varicella infection and the possible severe complications. They are safe with generally mild adverse effects. Cost-effectiveness studies show a benefit for the society. However, high vaccine coverage rates are needed to prevent the shift in varicella cases to older age groups. This can be achieved when administered in combination with the already established measles mumps rubella (MMR) vaccination at the age of 12 months.
Conclusion: Universal varicella vaccination is recommended if high coverage rates can be achieved.