Abstract
Respiratory infections caused by respiratory syncytial virus (RSV) are a significant cause of hospitalizations in young children. This study evaluates the impact of immunization with nirsevimab (Beyfortus®) on RSV-related hospitalizations and severity of outcome at Jessa Hospital, Belgium. Comparing pre- and post-immunization periods, data from the 2024–2025 RSV season show a reduction in hospitalizations, with a notable 78.7% decrease in infants under 6 months comparing to last season. Immunization resulted in reduced oxygen and Optiflow® need. Findings suggest that nirsevimab decreases hospitalizations and severity of RSV infections.