Syndromic Meningoencephalitis Panels - Multiplex PCR : the Limits of an Innovative Tool

Abstract

The main challenge in a clinical presentation of meningoencephalitis lies in the early detection of a pathogens in the cerebrospinal fluid. Owing to their rapid results and imperviousness to prior antibiotic use, syndromic panels using multiplex PCR have emerged as an innovative tool for the etiological diagnosis of meningoencephalitis.

However, this test presents limitations, as illustrated by two patient cases, one questionable and the other strongly suggestive of likely false-positive result for Haemophilus influenzae on multiplex PCR.
This case report highlights the importance of interpreting the results provided by this technique by integrating the patient's clinical and biological data.