An Unusual Skin Reaction after Bexsero® Vaccination in a Paediatric Patient: A Case Report

Abstract

Bexsero® is a multicomponent vaccine protecting against Neisseria meningitidis serogroup B, a major cause of meningococcal disease. Common side effects include injection site reactions (pain, redness, swelling) and systemic symptoms (fever, irritability, fatigue), while rarer complications like febrile seizures and Kawasaki disease occur in less than 1%. This case report describes a previously undocumented reaction in a twelve-week-old infant who developed immediate pale spots on the leg after vaccination, later progressing to a necrotic lesion. Possible hypotheses, including an immune response, intra-arterial injection with embolization, and vasospasm, are discussed.