Belgian Journal of Paediatrics
Triple A Syndrome Presenting as Hypoglycemic Convulsions in a 3-Year-Old Boy: A Case Report
Vol. 27 No. 1 (2025), Case reports
Vol. 27 No. 1 (2025)

Triple A Syndrome Presenting as Hypoglycemic Convulsions in a 3-Year-Old Boy: A Case Report

Case reports
Published 2025-04-29
Mariam Ouald Chaib
University of Antwerp, Antwerp University Hospital, department of Pediatrics, Edegem, Belgium
Mark Van Oort
University of Antwerp, Antwerp University Hospital, department of Pediatrics, Edegem, Belgium
Abdelhalim Ouald Chaib
Clinique Internationale de Tanger, department of Pediatrics, Tanger, Morocco
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Keywords

Triple A syndrome
alacrima
achalasia
ACTH-resistant adrenal insufficiency

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How to Cite

Ouald Chaib, M., Van Oort, M., & Ouald Chaib, A. (2025). Triple A Syndrome Presenting as Hypoglycemic Convulsions in a 3-Year-Old Boy: A Case Report. Belgian Journal of Paediatrics, 27(1), 47–49. Retrieved from https://belgjpaediatrics.com/index.php/bjp/article/view/361
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Abstract

Triple A syndrome, characterized by the triad of alacrimia, achalasia, and adrenocorticotropic hormone (ACTH)-resistant adrenal insufficiency, is a rare and often underreported condition. We present the case of a 3-year-old boy who presented with hypoglycemic seizures unresponsive to glucose boluses. A detailed history revealed congenital alacrimia. The suspicion of Triple A syndrome led to the initiation of hydrocortisone therapy, which resulted in rapid symptom resolution and confirmed the diagnosis. Early recognition of this multisystemic genetic disorder is crucial, as a delay in diagnosis can be life-threatening.

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