Belgian Journal of Paediatrics
The influence of maternal antibodies on the immune responses of term and preterm born infants
Vol. 24 No. 3 (2022), Made in Belgium
Vol. 24 No. 3 (2022)

The influence of maternal antibodies on the immune responses of term and preterm born infants: Ph D thesis presented on 15 October 2021 at the University of Antwerp, Belgium

Made in Belgium
Published 2022-12-12 — Updated on 2023-01-17
Marjolein Orije
University of Ghent, Faculty of Medicine and Health Sciences, Department of Internal Medicine and Pediatrics
Elke Leuridan
Promoter, University of Antwerp, Centre for the Evaluation of Vaccination, Vaccine & Infectious Diseases Institute, Antwerp
Pierre Van Damme
Promoter, University of Antwerp, Centre for the Evaluation of Vaccination, Vaccine & Infectious Diseases Institute, Antwerp
Benson Ogunjimi
Promoter, University of Antwerp, Centre for Health Economics Research and Modelling Infectious Diseases (CHERMID) and Antwerp Center for Translational Immunology and Virology (ACTIV), Vaccine & Infectious Diseases Institute (VAXINFECTIO), Antwerp
Kirsten Maertens
Promoter, University of Antwerp, Centre for the Evaluation of Vaccination, Vaccine & Infectious Diseases Institute, Antwerp

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Keywords

vaccination
pregnancy
immune response
preterm infant
infant

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How to Cite

Orije, M., Leuridan, E., Van Damme, P., Ogunjimi, B., & Maertens, K. (2023). The influence of maternal antibodies on the immune responses of term and preterm born infants: Ph D thesis presented on 15 October 2021 at the University of Antwerp, Belgium. Belgian Journal of Paediatrics, 24(3), 229–232. Retrieved from https://belgjpaediatrics.com/index.php/bjp/article/view/36 (Original work published December 12, 2022)
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Abstract

Vaccination during pregnancy is effective in providing protection against vaccine-preventable diseases in young infants. Here, timely (second rather than third trimester) pertussis vaccination during pregnancy is recommended, conveying protection against Bordetella pertussis in term and preterm born infants. Additionally, breastfeeding during the first months of life can be advised to achieve additional mucosal protection. One must note that after infant vaccination, humoral and limited cellular interference by maternal antibodies was observed. However, clinical relevance of maternal interference has yet to be determined, as evidence of good serological and cellular immunogenicity against DTaP-IPV-HB-PRP~T vaccine after primary and booster vaccination was provided.

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