Belgian Journal of Paediatrics
Exploring the Interferon Signature
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Keywords

interferon
signature
type 1 interferonopathy
autoinflammation
transcriptomic

Categories

How to Cite

Bernard, A., Hilbert, P., & Brasseur, B. (2024). Exploring the Interferon Signature: Laboratory Elaboration and Clinical Perspectives. Belgian Journal of Paediatrics, 26(4), 293–297. Retrieved from https://belgjpaediatrics.com/index.php/bjp/article/view/283

Abstract

Type 1 interferonopathies encompass a group of autoinflammatory diseases in which overactivation of the type I interferon pathway is the keystone. In this article, we describe the elaboration and clinical aspects of the interferon signature (or score) at the level of these rare monogenic diseases, but also in more common rheumatologic conditions, discuss its potential implications for therapeutic options for patients, and open future perspectives of transcriptomic analysis in immunoinflammatory diseases.

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