Belgian Journal of Paediatrics
Rubella vaccine associated cutaneous granulomatous disease as initial manifestation of an inborn error of immunity: a case report
Vol. 24 No. 2 (2022), Case reports
Vol. 24 No. 2 (2022)

Rubella vaccine associated cutaneous granulomatous disease as initial manifestation of an inborn error of immunity: a case report

Case reports
Published 2022-07-12 — Updated on 2023-01-17
Shari Schroven
University Hospital Antwerp, Edegem, Belgium
Michal Ulicki
University Hospital Antwerp, Edegem, Belgium
Marieke De Bruyne
Center for Medical Genetics, Ghent University and Ghent University Hospital, Ghent, Belgium
Jeroen Van Kampen
Erasmus MC, Department of Viroscience, Rotterdam, The Netherlands
Caroline Bonroy
University Hospital Ghent, Ghent, Belgium
Vasiliki Siozopoulou
University Hospital Antwerp, Edegem, Belgium
Victoria Bordon
University Hospital Ghent, Ghent, Belgium
Julie Leysen
University Hospital Antwerp, Edegem, Belgium
Filomeen Haerynck
University Hospital Ghent, Ghent, Belgium
Koen Vanden Driessche
University Hospital Antwerp, Edegem, Belgium

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Keywords

iVDRV
rubella
PID
inborn error of immunity

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How to Cite

Schroven, S., Ulicki, M., De Bruyne, M., Van Kampen, J., Bonroy, C., Siozopoulou, V., Bordon, V., Leysen, J., Haerynck, F., & Vanden Driessche, K. (2023). Rubella vaccine associated cutaneous granulomatous disease as initial manifestation of an inborn error of immunity: a case report. Belgian Journal of Paediatrics, 24(2), 124–126. Retrieved from http://belgjpaediatrics.com/index.php/bjp/article/view/77 (Original work published July 12, 2022)
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Abstract

Immunodeficiency-related vaccine-derived rubella virus cutaneous granulomatous disease as the initial manifestation of an inborn error of immunity is rare. We present a case of a 17-month-old girl with a skin eruption, which started three weeks after a routine measles, mumps, and rubella vaccination. Immunofluorescence staining and PCR and sequencing confirmed the presence of rubella virus (vaccine strain). Whole exome-based primary immunodeficiency panel revealed a homozygous UNC13D 12-bp deletion, associated with familial hemophagocytic lymphohistiocytosis.

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