Belgian Journal of Paediatrics
Chronic obstructive cholestasis with gallbladder masses associated with invasive fungal infection in a preterm neonate: a case report.
Vol. 24 No. 4 (2022), Case reports
Vol. 24 No. 4 (2022)

Chronic obstructive cholestasis with gallbladder masses associated with invasive fungal infection in a preterm neonate: a case report.

Case reports
Published 2023-01-20
Anne Geurden
Department of neonatology, University Hospital of Antwerp and University of Antwerp, Antwerp, Belgium
Anneleen Engelen
Department of neonatology, University Hospital of Antwerp and University of Antwerp, Antwerp, Belgium
Luisa Vonghia
Department of gastroenterology and hepatology, University Hospital of Antwerp and University of Antwerp, Antwerp, Belgium
Nicolette Moes
Department of paediatrics, University Hospital of Antwerp and University of Antwerp, Antwerp, Belgium
Veerle Matheeussen
Department of clinical microbiology, University Hospital of Antwerp and University of Antwerp, Antwerp, Belgium
Bart Bracke
Department of hepatobiliary, transplant and endocrine surgery, University Hospital of Antwerp and University of Antwerp, Antwerp, Belgium
Koen Vanden Driessche
Department of paediatrics, University Hospital of Antwerp and University of Antwerp, Antwerp, Belgium
Ludo Mahieu
Department of neonatology, University Hospital of Antwerp and University of Antwerp, Antwerp, Belgium
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Keywords

case report
invasive fungal infection
preterm
obstructive cholestasis
beta-D-glucan

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How to Cite

Geurden, A., Engelen, A., Vonghia, L., Moes, N., Matheeussen, V., Bracke, B., Vanden Driessche, K. ., & Mahieu, L. (2023). Chronic obstructive cholestasis with gallbladder masses associated with invasive fungal infection in a preterm neonate: a case report. Belgian Journal of Paediatrics, 24(4), 306–309. Retrieved from http://belgjpaediatrics.com/index.php/bjp/article/view/20
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Abstract

A preterm boy, born at the gestational age of 26 weeks, developed a sepsis followed by cholestasis at the age of 4 weeks despite broad spectrum antibiotic and fluconazole treatment. Abdominal ultrasound showed masses of unknown origin in the gallbladder. An invasive fungal infection was presumptively diagnosed via serum 1-3-ß-D-glucan. After initiation of an echinocandin, CRP and cholestasis parameters diminished quickly and the patient recovered, which we believe confirmed the diagnosis.

Accumulation of fungal balls in the gallbladder has been described as a cause of chronic obstructive cholestasis in immunocompromised adults, this hadn’t yet been reported in a preterm neonate.

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