Belgian Journal of Paediatrics
Pulmonary Embolism complicated Acute Chest Syndrome and suspected SARS-CoV-2 infection in adolescents with Sickle Cell Disease
Vol. 23 No. 2 (2021), Case reports
Vol. 23 No. 2 (2021)

Pulmonary Embolism complicated Acute Chest Syndrome and suspected SARS-CoV-2 infection in adolescents with Sickle Cell Disease

Case reports
Published 2021-07-11 — Updated on 2023-01-18
Milena Demey
Department of Pediatrics –Hôpital Universitaire des Enfants Reine Fabiola (HUDERF) – Université Libre de Bruxelles (ULB) - Brussels – Belgium
Laurence Dedeken
Hematology-Oncology Unit– Hôpital Universitaire des Enfants Reine Fabiola (HUDERF) – Université Libre de Bruxelles (ULB) - Brussels – Belgium
Pierre Smeesters
Department of Pediatrics & Infectious Disease Unit – Hôpital Universitaire des Enfants Reine Fabiola (HUDERF) – Université Libre de Bruxelles (ULB) - Brussels – Belgium
Anne Tilmanne
Infectious Disease Unit – Hôpital Universitaire des Enfants Reine Fabiola (HUDERF) – Université Libre de Bruxelles (ULB) - Brussels – Belgium
Alina Ferster
Hematology-Oncology Unit– Hôpital Universitaire des Enfants Reine Fabiola (HUDERF) – Université Libre de Bruxelles (ULB) - Brussels – Belgium

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Keywords

sickle cell disease
COVID-19
acute chest syndrome
thromboembolic events

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How to Cite

Demey, M., Dedeken, L., Smeesters, P., Tilmanne, A., & Ferster, A. (2023). Pulmonary Embolism complicated Acute Chest Syndrome and suspected SARS-CoV-2 infection in adolescents with Sickle Cell Disease. Belgian Journal of Paediatrics, 23(2), 151–153. Retrieved from http://belgjpaediatrics.com/index.php/bjp/article/view/154 (Original work published July 11, 2021)
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Abstract

SARS-CoV-2 causes a hypercoagulable state that predisposes patients to thromboembolic events.  We report two adolescents with sickle cell disease who developed pulmonary embolism during an acute chest syndrome episode associated with a possible SARS-CoV-2 infection.  Both sickle cell disease and SARS-CoV-2 infection predispose to thromboembolic disease. Thromboprophylaxis with low molecular weight heparin should be considered in adolescent with acute chest syndrome, related or not to COVID-19 disease.

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